Jack has two sons. They are doctors now.
この二つの文を関係代名詞でつなげると、
Jack has two sons who are doctors now.
Jack has two sons. Both of them are doctors now.
この二つの文を関係代名詞でつなげると、
Jack has two sons, both of whom are doctors now.
Comma (,) の後には、space が1つ入りますので注意してください。